Butoconazole is an antifungal medication used to treat vaginal yeast infections. During the manufacturing process of butoconazole, impurities may be present that can impact the quality and safety of the medication. These impurities must be closely monitored and controlled to ensure the final product is pure and effective for patients. The most common impurities found in butoconazole include related substances, residual solvents, and degradation products. Methods for detecting and quantifying these impurities are important for ensuring product quality and safety.