Cascarosid impurities refer to the presence of unwanted substances in pharmaceutical preparations derived from the Cascarilla bark. These impurities may cause adverse effects on the patient's health and can affect the efficacy of the medication. It is crucial to identify and quantify these impurities to ensure the safety and quality of the drug product. Various analytical methods are available to detect and measure Cascarosid impurities, including high-performance liquid chromatography (HPLC) and mass spectrometry (MS).