Clodronic acid is a bisphosphonate drug used for the treatment of osteoporosis and hypercalcemia. However, during the manufacturing process, impurities may be introduced, which can affect the purity and potency of the final product. These impurities can include related compounds, degradation products, and residual solvents. It is important to monitor and control these impurities to ensure the safety and efficacy of Clodronic acid. Various analytical techniques such as HPLC and GC are used to detect and quantify these impurities.