Clofazimine is an antimicrobial drug used in the treatment of leprosy and other mycobacterial infections. It is important to ensure that the clofazimine used in these treatments is of high purity and free from any impurities that could potentially cause adverse effects. The impurities that may be present in clofazimine include related substances, degradation products, and residual solvents, which can be identified and quantified through analytical methods such as high-performance liquid chromatography (HPLC) and gas chromatography (GC). The control and monitoring of clofazimine impurities are critical to ensuring the safety and efficacy of the drug.