Histamine impurities are unwanted substances that can be found in various types of products, including food, drugs, and cosmetics. These impurities are formed when the amino acid histidine is broken down by bacteria or enzymes. Exposure to high levels of histamine impurities can cause adverse reactions in some individuals, such as headaches, skin rashes, and gastrointestinal issues. Therefore, it is important to monitor and control histamine levels in products to ensure their safety for consumption or use.