Histidine impurities refer to the presence of unwanted or unintended amounts of histidine in a substance or product. This can occur during the manufacturing process or as a result of environmental factors. Histidine is an amino acid that is essential for many biological processes, but excessive amounts can lead to negative effects on health and product quality. Effective monitoring and control of histidine impurities is crucial to ensure the safety and efficacy of pharmaceuticals, food products, and other substances.