Iguratimod is a medication used to treat rheumatoid arthritis. However, during the manufacturing process, impurities may be present in the final product. These impurities can affect the safety and efficacy of the medication. Therefore, it is important to identify and quantify these impurities to ensure the quality of the medication. Various analytical techniques such as HPLC, LC-MS, and GC-MS are used for the identification and characterization of Iguratimod impurities.