Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that is widely used to treat pain and inflammation associated with various medical conditions. However, like any other pharmaceutical product, indomethacin may contain impurities that can affect its quality, safety, and efficacy. Indomethacin impurities are the unwanted substances or by-products that may arise during the manufacturing, storage, or transportation of the drug. These impurities can be organic or inorganic in nature and may pose a risk to human health if present in significant amounts. Therefore, the identification, characterization, and control of indomethacin impurities are critical for ensuring the quality and safety of the drug product.