Liothyronine is a synthetic thyroid hormone used to treat hypothyroidism. However, during the manufacturing process, impurities may be introduced that can affect the purity and potency of the drug. These impurities can also have harmful effects on the patient's health. Therefore, it is essential for pharmaceutical companies to monitor and control the impurities in Liothyronine to ensure its safety and efficacy. Analytical techniques such as high-performance liquid chromatography (HPLC) and gas chromatography (GC) are used to detect and quantify these impurities.