Lofexidine is a medication used to treat opioid withdrawal symptoms. As with any medication, impurities may be present in the drug substance or drug product. Lofexidine impurities are unwanted compounds that can affect the quality, safety, and efficacy of the drug. The identification, characterization, and control of these impurities are crucial to ensure the purity and quality of the final product. Analytical methods such as high-performance liquid chromatography (HPLC) are commonly used to detect and quantify impurities in pharmaceuticals.