Simethicone is a commonly used antifoaming agent used in medicines to relieve symptoms of gas and bloating. However, during the manufacturing process of Simethicone, impurities may be formed which can affect the quality and safety of the final product. These impurities may include residual solvents, heavy metals, and other harmful substances. Therefore, it is important to monitor and control the levels of Simethicone impurities to ensure the safety and efficacy of the medicine.