Sisomicin is an antibiotic medication used to treat severe bacterial infections. Sisomicin impurities are unwanted substances that can be present in sisomicin formulations. These impurities can affect the purity and quality of the medication, potentially reducing its effectiveness and causing harmful side effects. It is essential to control and monitor sisomicin impurities to ensure the safety and efficacy of the medication. Various analytical techniques are employed to identify and quantify sisomicin impurities, enabling manufacturers to produce high-quality sisomicin formulations.