Imatinib N-Desmethyl Impurity
| Product Name | Imatinib N-Desmethyl Impurity |
|---|---|
| Alternate Names | Imatinib Impurities, Impurities of Imatinib |
| CAT No. | CS-O-05955 |
| CAS No. | 404844-02-6 |
| Category | Impurities |
| Stock | IN-Stock |
| Mol. Wt. | 479.58 g/mol |
| Mol. For. | C₂₈H₂₉N₇O |
| Hazardous | This is a Hazardous Compound |
| COA | View Sample COA |
| MSDS | View Sample MSDS |
| Parent API | Imatinib |
| Purity | >98% |
| Therapeutic | Anti-Cancer / Oncology, Anti Neo Plastic Agents |
| Smileys | CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCNCC3)NC4=NC=CC(=N4)C5=CN=CC=C5 |
| Canonical Smiles | CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCNCC3)NC4=NC=CC(=N4)C5=CN=CC=C5 |
| InchIKey | BQQYXPHRXIZMDM-UHFFFAOYSA-N |
| Inchl | InChI=1S/C28H29N7O/c1-20-4-9-24(17-26(20)34-28-31-12-10-25(33-28)23-3-2-11-30-18-23)32-27(36)22-7-5-21(6-8-22)19-35-15-13-29-14-16-35/h2-12,17-18,29H,13-16,19H2,1H3,(H,32,36)(H,31,33,34) |
| IUPAC | N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-4-(piperazin-1-ylmethyl)benzamide |
| Controlled | No |
| Shipping | Free for purchase above 1000$ |
| Delivery | In-Stock, products will be dispatched within 24 hours via FedEx for USA, Europe, and other countries. |
| Return | Returns/replacement accepted if you are not satisfied with the quality of the product, (please send us an email with the reason/issues which are facing, within 15 days, after receipt of the product). |
| Ordering | Place your order online or by email sales@clearsynth.com |
Imatinib is a potent tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia and gastrointestinal stromal tumors. However, during the synthesis and storage of Imatinib, its N-Desmethyl Impurity can be formed. This impurity, also known as CGP74588, is a structurally related compound that lacks one of the methyl groups present in Imatinib.
The N-Desmethyl Impurity of Imatinib is a minor component that can be present at levels of less than 1% in the final product. Although it does not affect the efficacy of Imatinib, it is important to monitor its levels as it can impact the stability, shelf-life, and safety of the drug product. In addition, the presence of impurities in pharmaceuticals is regulated by various health authorities and must be controlled within acceptable limits.
From a chemical perspective, Imatinib N-Desmethyl Impurity has a molecular weight of 494.54 g/mol and a molecular formula of C28H23N7O. It is a yellowish-brown solid with a melting point of 227-229°C. The impurity is relatively stable and can be stored for extended periods without significant degradation.
In conclusion, while the N-Desmethyl Impurity of Imatinib may seem insignificant, it is essential to monitor its levels during the synthesis and storage of the drug product. Understanding its chemical properties and usage can ensure the safety and efficacy of Imatinib for patients.
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Related Compounds
N-Nitroso Imatinib Nitro Intermediate | N-(2-Methyl-5-nitrophenyl)-4-(pyridine-3-yl)pyridine-2-amine | Fluorescent derivative of imatinib | Imatinib EP Impurity D Tetrahydrochloride | N-Boc-N-Desmethyl Imatinib | N-Nitroso Imatinib | Imatinib EP Impurity C Trihydrochloride | Imatinib Impurity B | Imatinib Impurity 5 | Imatinib Imidazole Impurity | N-(3-methyl5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4((4-methylpiperazin-1-yl)methyl)benz | Imatinib EP Impurity D | Imatinib Dimethylamino Impurity | Imatinib N-Acetyl Impurity | Imatinib Impurity 3 | Imatinib EP Impurity C | Imatinib N-Formyl Impurity | N-Desmethyl -n-nitroso imatinib 1 | Imatinib (Piperazine)-N4-Oxide | N-Desmethyl Imatinib Mesylate | Imatinib (N-nitroso benzamide) | N-Nitroso Imatinib impurity F | Imatinib Hydrochloride Impurity G | Imatinib Dimer | Imatinib impurity B | Imatinib DiPiperazine Impurity | Imatinib Impurity 16 | N-Desmethyl -N-Nitroso Imatinib | Imatinib (Pyridine)-N-oxide | Imatinib Guanidino Dihydrochloride Impurity | Imatinib EP Impurity D (chloride) | Des-4-methylpiperazin chloro Imatinib impurity | N-Nitroso Imatinib guanidine Intermediate |