Nilotinib D3

Product Name Nilotinib D3
CAT No. CS-O-10540
CAS No. 1215678-43-5
Category Stable Isotopes
Stock IN-Stock
Mol. Wt. 532.53 g/mol
Mol. For. C₂₈H₁₉D₃F₃N₇O
Hazardous This is a Hazardous Compound
COA View Sample COA
MSDS View Sample MSDS
Therapeutic Anti-Cancer / Oncology
Smileys CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
Canonical Smiles CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
InchIKey HHZIURLSWUIHRB-BMSJAHLVSA-N
Inchl InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)/i2D3
IUPAC 4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-N-[3-[4-(trideuteriomethyl)imidazol-1-yl]-5-(trifluoromethyl)phenyl]benzamide
Controlled No
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Nilotinib D3 is a deuterated form of the drug Nilotinib, which is a tyrosine kinase inhibitor used in the treatment of chronic myelogenous leukemia (CML). It works by inhibiting the activity of an abnormal protein called BCR-ABL, which is responsible for the growth and survival of cancer cells in CML patients. Nilotinib D3 is used in research and clinical studies to determine the pharmacokinetic properties of Nilotinib and to help identify any potential drug-drug interactions that may occur. Chemically, Nilotinib D3 is a white to off-white powder with a molecular formula of C28H23D3ClN6O and a molecular weight of 503.02 g/mol. It is soluble in methanol and slightly soluble in water. The deuterium substitution in Nilotinib D3 helps to improve the drug’s metabolic stability and bioavailability, resulting in a longer half-life and more efficient delivery to cancer cells. Nilotinib D3 is typically administered orally in the form of capsules, and the recommended dosage varies depending on the patient’s weight and medical history. Common side effects of Nilotinib D3 include nausea, vomiting, diarrhea, and skin rash. Patients should also be monitored for any signs of liver toxicity and heart problems, as Nilotinib can cause these complications in some cases. Overall, Nilotinib D3 is a valuable tool for researchers and clinicians working to improve the treatment of CML and other types of cancer. Its unique chemical properties and therapeutic benefits make it an important addition to the arsenal of drugs used in the fight against cancer.

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