CAS No.
[364782-34-3 (unlabelled)]
Storage Condition
Refer MSDS for complete information
Synonyms
(R)-Cinacalcet-D3 Hydrochloride, 364782-34-3 (unlabelled)
Application Notes
Useful research chemical for a range of applications
Hazard Compound
Refer MSDS for complete information
(R)-Cinacalcet-D3 Hydrochloride is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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(R)-Cinacalcet-D3 Hydrochloride usage and description
(R)-Cinacalcet-D3 Hydrochloride is a chemical compound that is used as a medication for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. It is a synthetic analog of calcimimetic cinacalcet that has been deuterated to enhance its stability and efficacy. The compound works by binding to the calcium-sensing receptor on the parathyroid gland, which regulates the secretion of parathyroid hormone (PTH). This results in a decrease in the secretion of PTH, which in turn reduces the levels of calcium and phosphorus in the blood.
The chemical formula of (R)-Cinacalcet-D3 Hydrochloride is C22H19D3ClF2N, and its molecular weight is 370.90 g/mol. It is an off-white to pale yellow crystalline powder that is sparingly soluble in water and soluble in methanol and ethanol. The compound is typically administered as an oral tablet, with a recommended starting dose of 30 mg once daily. The dose may be adjusted based on the patient's response and serum calcium levels.
(R)-Cinacalcet-D3 Hydrochloride is metabolized in the liver and excreted in the feces and urine. It is primarily metabolized by cytochrome P450 enzymes, particularly CYP3A4 and CYP2D6. The half-life of the compound is approximately 30-40 hours, and it takes about 5-7 days to reach steady-state concentrations in the blood.
Overall, (R)-Cinacalcet-D3 Hydrochloride is an effective medication for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease. Its deuterated analog enhances its stability and efficacy, making it a valuable addition to the armamentarium of treatments for this condition.
