- Synonyms:Docetaxel Impurity E
- Chemical Name:[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12,15-tetrahydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
- Country of Origin:India
- Application Notes:"Impurity in commerial preparation of Baccatin.;Impurity in commercial preparations of Baccatin. Cabazitaxel intermediate. 10-Deacetylbaccatin III is an inhibitor of microtubule assembly (IC50s = 23 and 0.9 ?M for porcine brain and Physaram microtubules, respectively) found in T. baccata extracts.1 It is a precursor in the semisynthetic synthesis of paclitaxel (Item No. 10461) and other semisynthetic toxoids.2 10-Deacetylbaccatin III also selectively inhibits growth of L. donovani intracellular amastigotes within J774 murine macrophages (IC50 = 70 nM), while having no effect on macrophage morphology.3"
- Product Category:Baccatin Impurities
10-Deacetylbaccatin III is identified by CAS No. 32981-86-5 and is chemically known as Docetaxel Impurity E , IUPAC Name: [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12,15-tetrahydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate.
10-Deacetylbaccatin III is provided with comprehensive characterization data in accordance with regulatory guidelines. It is suitable for use in analytical method development, method validation (AMV), Quality Control (QC) applications for Abbreviated New Drug Applications (ANDA) and commercial production of Baccatin.
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