Product Detail
Docetaxel - Impurity E
Baccatin Impurity
Stock Status: In Stock
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For Research & Analytical Purposes. Not for Personal use.
Category
Impurity
API Family
Baccatin
Storage
Store at refrigerator (2-8°C) for long term storage
Hazard Information
Refer MSDS for accurate information.
Docetaxel - Impurity E Product Information
Docetaxel - Impurity E is listed under Impurity. It is associated with Baccatin and is intended for analytical research, quality control and pharmaceutical reference standard applications. The product is supplied by Clearsynth under CAT No. CS-O-31076.
Clearsynth provides this compound for research and analytical use, with product information including CAS number, molecular formula, molecular weight, stock enquiry details and supporting documentation.
Technical Data
Product Name
Docetaxel - Impurity E
CAS No.
32981-86-5
CAT No.
CS-O-31076
Molecular Formula
C₂₉H₃₆O₁₀
Molecular Weight
544.59
Category
API Family
Storage Condition
Store at refrigerator (2-8°C) for long term storage
IUPAC Name
(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-4,6,9,11-
tetrahydroxy4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12bdodecahydro-1H7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
Purity by HPLC
Not less than 90%
Hazard Compound
Refer MSDS for accurate information.
Description
Overview
"Impurity in commerial preparation of Baccatin.;Impurity in commercial preparations of Baccatin. Cabazitaxel intermediate. 10-Deacetylbaccatin III is an inhibitor of microtubule assembly (IC50s = 23 and 0.9 ?M for porcine brain and Physaram microtubules, respectively) found in T. baccata extracts.1 It is a precursor in the semisynthetic synthesis of paclitaxel (Item No. 10461) and other semisynthetic toxoids.2 10-Deacetylbaccatin III also selectively inhibits growth of L. donovani intracellular amastigotes within J774 murine macrophages (IC50 = 70 nM), while having no effect on macrophage morphology.3"
Synonyms
-
Application Notes
"Impurity in commerial preparation of Baccatin.;Impurity in commercial preparations of Baccatin. Cabazitaxel intermediate. 10-Deacetylbaccatin III is an inhibitor of microtubule assembly (IC50s = 23 and 0.9 ?M for porcine brain and Physaram microtubules, respectively) found in T. baccata extracts.1 It is a precursor in the semisynthetic synthesis of paclitaxel (Item No. 10461) and other semisynthetic toxoids.2 10-Deacetylbaccatin III also selectively inhibits growth of L. donovani intracellular amastigotes within J774 murine macrophages (IC50 = 70 nM), while having no effect on macrophage morphology.3"
References
"Lataste, H,,Senilh, V,,Wright, M,, et al; Proc, Natl, Acad, Sci, USA 81(13), 4090-4094 (1984),"