Storage Condition
Store at refrigerator (2-8ยฐC) for long term storage
Synonyms
2,2โฒ-Anhydro(1-ฮฒ-D-arabinofuranosyl)uracil
Application Notes
Useful research chemical for a range of applications
Hazard Compound
No -Refer MSDS for accurate information
2,2-O-Cyclouridine is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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2,2-O-Cyclouridine usage and description
2,2-O-Cyclouridine is a modified nucleoside that has gained interest in recent years due to its potential use in the development of nucleic acid-based therapeutics. This molecule consists of a uridine base that has been cyclized at the 2' and 2'' positions through the formation of an ether linkage, resulting in a unique cyclic structure.
One of the key applications of 2,2-O-Cyclouridine is in the development of antisense oligonucleotides (ASOs). ASOs are short, synthetic nucleic acid sequences that can bind to specific target RNA molecules and modulate their activity. By incorporating 2,2-O-Cyclouridine into ASOs, researchers have demonstrated improved binding affinity, nuclease resistance, and cellular uptake compared to traditional oligonucleotides.
In addition to its use in ASOs, 2,2-O-Cyclouridine has also been investigated for its potential as a prodrug. Prodrugs are inactive compounds that can be converted into active drugs within the body, usually through enzymatic or chemical reactions. In the case of 2,2-O-Cyclouridine, it can be converted into a potent antiviral agent known as 2'-C-methylcytidine. This prodrug approach has shown promise in the treatment of viral infections such as hepatitis C and respiratory syncytial virus.
From a chemical standpoint, 2,2-O-Cyclouridine is a stable molecule that is resistant to hydrolysis and enzymatic degradation. Its unique cyclic structure also confers increased rigidity and conformational stability compared to linear nucleosides. These properties make it an attractive building block for the development of nucleic acid-based drugs and therapeutics.
