Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
(S)-2,2-diphenyl-2-(pyrrolidin-3-yl)acetonitrile hydrobromide
Application Notes
Useful research chemical for a range of applications
Hazard Compound
No -Refer MSDS for accurate information
2,2-Diphenyl-2-((R)-pyrrolidin-3-yl)acetonitrile hydrobromide is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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2,2-Diphenyl-2-((R)-pyrrolidin-3-yl)acetonitrile hydrobromide usage and description
2,2-Diphenyl-2-((R)-pyrrolidin-3-yl)acetonitrile hydrobromide, also known as DPA-HBr, is a chemical compound used in medicinal chemistry as a chiral stationary phase for the separation of enantiomers. It is a white to off-white crystalline powder that is soluble in water and methanol.
DPA-HBr has a molecular formula of C20H21N2Br and a molecular weight of 372.3 g/mol. It is a derivative of pyrrolidine, a cyclic secondary amine that is commonly used as a building block in organic synthesis. The acetonitrile group in DPA-HBr enhances its solubility and stability in aqueous solutions.
The hydrobromide salt of DPA is commonly used in analytical chemistry as a chiral selector for HPLC (high-performance liquid chromatography) and GC (gas chromatography) separations. The chiral center in the pyrrolidine ring of DPA allows for the separation of enantiomers based on their differential interaction with the chiral stationary phase.
DPA-HBr has also been studied as a potential therapeutic agent for the treatment of neurological disorders such as Alzheimer’s disease and Parkinson’s disease. It has been shown to have neuroprotective effects by inhibiting the aggregation of amyloid-beta peptides, which are implicated in the pathogenesis of Alzheimer’s disease.
In conclusion, 2,2-Diphenyl-2-((R)-pyrrolidin-3-yl)acetonitrile hydrobromide is a versatile chemical compound with diverse applications in medicinal and analytical chemistry. Its unique chiral properties make it a valuable tool for the separation of enantiomers, while its neuroprotective effects hold promise for the treatment of neurological disorders.
