Therapeutic Uses
Anti-Cancer / Oncology
Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-[di(methyl-d3)amino]-2-butenamide
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
Refer MSDS for complete information
Afatinib-d6 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
We are committed to offering products of the highest quality in order to meet the needs of our customers, and have elaborate systems in
place to ensure that material specifications, their certification and all handling and storage conditions are communicated at the time of
material handover.
We have invested in the highest quality packaging materials and use international logistics partners to service our customers. While all
possible precautions have been taken to deliver the required product(s), there may be some rare situations when our product does not
meet your requirements. Should that arise, please contact us with your concerns and we will endeavour to address them on a priority
basis. If there is no other option, we will either replace your product(s) or issue a refund or account credit, whichever you prefer.
If there is an issue with one or more of our products, our policy is that it must be reported to us within 45 days of your receiving shipment.
While we will always address product issues after the 45 day return window has passed, we cannot issue a refund or account credit. As
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Afatinib-d6 usage and description
Afatinib D6 is a deuterated analog of afatinib, which is a selective inhibitor of the epidermal growth factor receptor (EGFR) family of tyrosine kinases. The deuterium atom in Afatinib D6 replaces one of the hydrogen atoms in the original afatinib molecule, making it useful as a reference standard for drug metabolism studies.
Afatinib D6 is most commonly used in research studies to determine its pharmacokinetics and metabolism in humans. It is also used in preclinical studies to investigate the mechanisms of action of afatinib and to develop new therapeutic strategies for cancer treatment.
The chemical formula of Afatinib D6 is C24H18D6ClFN4O3, and its molecular weight is 490.99 g/mol. It is a white to off-white crystalline powder that is soluble in water, ethanol, and dimethyl sulfoxide.
Afatinib D6 is a potent inhibitor of EGFR and HER2 tyrosine kinases, which are overexpressed in various types of cancer, including non-small cell lung cancer, breast cancer, and head and neck squamous cell carcinoma. By blocking the activity of these kinases, Afatinib D6 can inhibit cancer cell growth and induce apoptosis, leading to tumor shrinkage and improved patient outcomes.
In conclusion, Afatinib D6 is a valuable tool for investigating the pharmacokinetics and metabolism of afatinib, and for developing new cancer therapies targeting EGFR and HER2 kinases.
