M.F.
CโโHโโDโClFNโ
Oโ
Therapeutic Uses
Anti-Cancer / Oncology
Storage Condition
Store at refrigerator (2-8ยฐC) for long term storage
Synonyms
(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-[di(methyl-d3)amino]-2-butenamide
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
Refer MSDS for complete information
Afatinib-d6 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
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Afatinib-d6 usage and description
Afatinib D6 is a deuterated analog of afatinib, which is a selective inhibitor of the epidermal growth factor receptor (EGFR) family of tyrosine kinases. The deuterium atom in Afatinib D6 replaces one of the hydrogen atoms in the original afatinib molecule, making it useful as a reference standard for drug metabolism studies.
Afatinib D6 is most commonly used in research studies to determine its pharmacokinetics and metabolism in humans. It is also used in preclinical studies to investigate the mechanisms of action of afatinib and to develop new therapeutic strategies for cancer treatment.
The chemical formula of Afatinib D6 is C24H18D6ClFN4O3, and its molecular weight is 490.99 g/mol. It is a white to off-white crystalline powder that is soluble in water, ethanol, and dimethyl sulfoxide.
Afatinib D6 is a potent inhibitor of EGFR and HER2 tyrosine kinases, which are overexpressed in various types of cancer, including non-small cell lung cancer, breast cancer, and head and neck squamous cell carcinoma. By blocking the activity of these kinases, Afatinib D6 can inhibit cancer cell growth and induce apoptosis, leading to tumor shrinkage and improved patient outcomes.
In conclusion, Afatinib D6 is a valuable tool for investigating the pharmacokinetics and metabolism of afatinib, and for developing new cancer therapies targeting EGFR and HER2 kinases.