Therapeutic Uses
Anti-Cancer / Oncology
Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
N-[4-(1-cyanocyclopentyl-2,2,3,3,4,4,5,5-d8)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
No -Refer MSDS for accurate information
Apatinib-d8 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
We are committed to offering products of the highest quality in order to meet the needs of our customers, and have elaborate systems in
place to ensure that material specifications, their certification and all handling and storage conditions are communicated at the time of
material handover.
We have invested in the highest quality packaging materials and use international logistics partners to service our customers. While all
possible precautions have been taken to deliver the required product(s), there may be some rare situations when our product does not
meet your requirements. Should that arise, please contact us with your concerns and we will endeavour to address them on a priority
basis. If there is no other option, we will either replace your product(s) or issue a refund or account credit, whichever you prefer.
If there is an issue with one or more of our products, our policy is that it must be reported to us within 45 days of your receiving shipment.
While we will always address product issues after the 45 day return window has passed, we cannot issue a refund or account credit. As
always, we appreciate your support.
Apatinib-d8 usage and description
Apatinib D8 is a deuterated form of Apatinib, a tyrosine kinase inhibitor used in the treatment of advanced gastric cancer and other solid tumors. It is an orally administered small molecule drug designed to selectively inhibit the vascular endothelial growth factor receptor-2 (VEGFR-2) signaling pathway. The drug has shown promising results in clinical trials, demonstrating its efficacy in treating various types of cancers.
Apatinib D8 is a white to off-white powder that is moderately soluble in water and ethanol. Its chemical formula is C24H23D8N5O3, and its molecular weight is 461.59 g/mol. The deuterated form of Apatinib has a higher mass than its non-deuterated counterpart, which is useful in pharmacokinetic studies for determining drug absorption, distribution, metabolism, and excretion.
The drug works by blocking the VEGFR-2 pathway, which is involved in tumor angiogenesis, the process by which new blood vessels are formed to supply oxygen and nutrients to cancer cells. By inhibiting this pathway, Apatinib D8 can prevent the growth and spread of cancer cells, leading to tumor shrinkage and improved patient outcomes.
In conclusion, Apatinib D8 is a promising drug in the fight against cancer. Its unique chemical properties and mechanism of action make it a valuable tool for researchers and clinicians in the ongoing battle against this deadly disease.
