CAS No.
[761373-05-1Unlabelled]
Storage Condition
Refer MSDS for complete information
Synonyms
(2S,4R)-Sacubitril D4, 761373-05-1Unlabelled
Application Notes
Useful research chemical for a range of applications
Hazard Compound
Refer MSDS for complete information
(2S,4R)-Sacubitril D4 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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(2S,4R)-Sacubitril D4 usage and description
(2S,4R)-Sacubitril D4 is a deuterated form of the drug sacubitril, which is used in combination with valsartan to treat heart failure. The drug works by inhibiting neprilysin, an enzyme that breaks down substances in the body that are involved in regulating blood pressure and fluid balance. By inhibiting neprilysin, sacubitril D4 helps to increase levels of these substances, which can help to improve heart function and reduce symptoms of heart failure.
Chemically, sacubitril D4 is a white to off-white crystalline powder that is soluble in water and ethanol. Its molecular formula is C24H31D4NO5 and its molecular weight is 441.6 g/mol. Like sacubitril, sacubitril D4 is metabolized in the liver to its active form, LBQ657, which is responsible for the drug's therapeutic effects.
Sacubitril D4 is typically administered orally in the form of tablets, with dosages ranging from 24 mg to 97 mg twice daily depending on the patient's condition. The drug should be taken with or without food, but should not be crushed or chewed. It is important to follow your doctor's instructions when taking this medication, as it can interact with other drugs and cause side effects such as dizziness, fatigue, and low blood pressure. Overall, sacubitril D4 is an important tool in the treatment of heart failure and can help to improve quality of life for many patients.
