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Eplerenone

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Product Code: CS-O-01427 API Research Use Only
Eplerenone
Category
API
API Family
Eplerenone
Product Code
CS-O-01427
Research Status
For Laboratory Use

Eplerenone

Eplerenone API
Stock Status: In Stock
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CAT No.
CS-O-01427
CAS No.
107724-20-9
Molecular Formula
C₂₄H₃₀O₆
Molecular Weight
414.49
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There is no hazardous surcharge associated with this product.
There is no packaging charge associated with this product.
For Research Purposes only. Not for Personal or Veterinary use.
All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.
CAS No.
107724-20-9
Product Code
CS-O-01427
M.F.
C₂₄H₃₀O₆
M.W.
414.49
Smiles
O=C1C=C(C[C@@]2([H])C(OC)=O)[C@@](CC1)(C)[C@]34[C@]2([H])[C@@](CC[C@@]5(O6)CCC6=O)([H])[C@]5(C)C[C@@]3([H])O4
Category
API
API Family
Eplerenone
Storage Condition
Store at refrigerator (2-8°C) for long term storage
IUPAC Name
(2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-methyl 4a,6a-dimethyl-2,5'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[ cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate
References
"De Gasparo et al (1987) Three new epoxy-spirolctone derivatives:charcterization in vivo and in vitro, J,Pharmcol,Exp,Ther, 240 650, cMahon (2001) Rcent studies with eplerenone; a novel selctive aldosterone rceptor antagonist,curr,Opin,Pharmcol, 1 190,"
Synonyms
Not Available
Application Notes
"Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors."
Purity by HPLC
Not less than 95%
Hazard Compound
Refer MSDS for complete information.
Overview
"Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors."

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