Therapeutic Uses
Anti-Diabetic
Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
Simvastatin-d3 Lactone, 1002347-61-6
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
No -Refer MSDS for accurate information
Simvastatin-d3 Lactone is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Simvastatin-d3 Lactone usage and description
Simvastatin D3 Lactone is a deuterated analog of Simvastatin Lactone, which is a well-known statin drug used to lower cholesterol levels in the blood. Simvastatin D3 Lactone is a stable isotopic form of Simvastatin Lactone, which contains three deuterium atoms instead of hydrogen atoms.
The chemical structure of Simvastatin D3 Lactone is similar to Simvastatin Lactone, except for the presence of deuterium atoms. It inhibits the enzyme HMG-CoA reductase, which is responsible for the conversion of HMG-CoA to mevalonate. Mevalonate is a precursor of cholesterol, and the inhibition of HMG-CoA reductase reduces the production of cholesterol.
Simvastatin D3 Lactone is used in research as a stable isotope-labeled internal standard for the quantification of Simvastatin Lactone in biological samples. It is also used in pharmacokinetic and metabolic studies of Simvastatin Lactone.
The pharmacological and toxicological properties of Simvastatin D3 Lactone are similar to those of Simvastatin Lactone. The deuterium substitution does not affect the pharmacodynamic properties of Simvastatin Lactone. However, the pharmacokinetic properties of Simvastatin D3 Lactone are different from Simvastatin Lactone due to the difference in molecular weight.
In summary, Simvastatin D3 Lactone is a useful tool in research for the quantification and metabolic studies of Simvastatin Lactone. Its chemical properties are similar to Simvastatin Lactone, but the deuterium substitution provides unique advantages in analytical and pharmacokinetic studies.
