Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
Hydroxy Bosentan-d6, 1246817-57-1
Application Notes
Useful research chemical for a range of applications
Hazard Compound
No -Refer MSDS for accurate information
Hydroxy Bosentan-d6 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
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Hydroxy Bosentan-d6 usage and description
Hydroxy Bosentan D6 is a stable labeled isotopic form of the drug Bosentan, which is an endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension. This compound is used as an internal standard in pharmacokinetic and metabolic studies of Bosentan, allowing for the precise quantification of metabolites and accurate assessment of drug interactions.
Chemically, Hydroxy Bosentan D6 is a derivative of Bosentan that has six deuterium atoms incorporated into its structure, specifically in the hydroxyl group at position 4 of the benzenesulfonamide ring. This stable isotope labeling ensures that the compound behaves identically to the unlabeled drug in terms of its physicochemical properties and biological activity, while also allowing for its easy detection and quantification using mass spectrometry.
In terms of usage, Hydroxy Bosentan D6 is typically used as an internal standard in analytical methods such as liquid chromatography-tandem mass spectrometry (LC-MS/MS) to accurately measure the levels of Bosentan and its metabolites in biological samples. Its use in pharmacokinetic studies allows for the precise determination of drug exposure and clearance rates, as well as the identification of potential drug-drug interactions.
Overall, Hydroxy Bosentan D6 plays a critical role in the development and evaluation of Bosentan as a therapeutic agent, and its use in analytical methods ensures the accuracy and reliability of data generated in these studies.
