Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl-1,1,2,2-D4]amino]ethyl]phenyl]-methanesulfonamide
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
No -Refer MSDS for accurate information
Dofetilide-d4 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
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Dofetilide-d4 usage and description
Dofetilide D4 is a deuterated version of the antiarrhythmic drug Dofetilide, which is commonly used to treat atrial fibrillation and atrial flutter. The deuterated version of the drug is used in research studies to help identify and track the drug's metabolic pathway and to study its pharmacokinetics.
Dofetilide D4 works by blocking the potassium ion channels in the heart muscle cells, which slows down the electrical activity in the heart and helps to restore normal heart rhythm. The drug is administered orally and is rapidly absorbed by the body, with peak plasma concentrations reached within two to three hours of ingestion. The drug is metabolized primarily by the liver and eliminated from the body via the kidneys.
The deuterated version of Dofetilide, Dofetilide D4, is useful in studies where the metabolic pathway of the drug needs to be tracked. Deuterium is a stable isotope of hydrogen, and its incorporation into the drug molecule allows researchers to identify specific breakdown products of the drug in the body. This information can be used to better understand the drug's pharmacokinetics and to optimize dosing regimens.
In conclusion, Dofetilide D4 is a useful tool for researchers studying the pharmacokinetics and metabolic pathways of the antiarrhythmic drug Dofetilide. Its incorporation of deuterium allows for more precise tracking of the drug's breakdown products, which can be used to optimize dosing regimens and improve treatment outcomes for patients with atrial fibrillation and atrial flutter.
