Smiles
O=C1C=2N(N=C(C(N)=O)C2CCN1C3=CC=C(C=C3)N4C(=O)CCCC4)C5=CC=C(O[13C]([2H])([2H])[2H])C=C5
Therapeutic Uses
Anti-Thrombotics
Storage Condition
Store at refrigerator (2-8°C) for long term storage
IUPAC Name
1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide-13CD3
References
"Luettgen; J,M, et al,: J, Enz, Inhib, Med,chem,; 26; 514 (2011); Glanis; T, et al,: J, Thromb, Thrombol,; 31; 310 (2011); barrett; Yc, et al,: Thromb, Haemos,; 105; 181 (2011);"
Synonyms
1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide-13CD3
Application Notes
"Labeled Apixaban, intended for use as an internal standard for the quantification of Apixaban by GC- or LC-mass spectrometry."
Purity by HPLC
Not less than 95 %
Hazard Compound
Refer MSDS for accurate information
Apixaban-13C,d3 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
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Apixaban-13C,d3 usage and description
Apixaban 13C D3 is a stable isotope labeled version of Apixaban, an oral anticoagulant medication used to reduce the risk of stroke and blood clots in patients with atrial fibrillation, deep vein thrombosis, and pulmonary embolism. The stable isotope labeling allows for precise analysis of the drug's pharmacokinetics, metabolism, and excretion in clinical studies.
The chemical formula of Apixaban 13C D3 is C25H25N5O4S, with a molecular weight of 489.57 g/mol. The labeled carbon atoms (13C) in the drug molecule allow for accurate determination of the drug's fate in the body through techniques such as mass spectrometry.
Apixaban works by inhibiting Factor Xa, a key enzyme in the coagulation cascade. This prevents the formation of blood clots and reduces the risk of stroke and other thromboembolic events. The drug has a half-life of approximately 12 hours and is primarily metabolized by the liver.
Apixaban 13C D3 is used in clinical research to investigate the pharmacokinetics and pharmacodynamics of the drug in various patient populations. It is also used in drug-drug interaction studies to determine how other medications may affect the metabolism and efficacy of Apixaban.
Overall, Apixaban 13C D3 is a valuable tool in drug development and clinical research, providing critical information on the safety and efficacy of Apixaban in patients.
