CAS No.
[1188-38-1(Unlabelled)]
API Family
Carglumic Acid
Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
(2S)-2-(carbamoylamino-15N)(1,2,3,4,5-13C5)pentanedioic acid
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 95 %
Hazard Compound
No -Refer MSDS for accurate information
Carglumic acid-13C5,15N is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Carglumic acid-13C5,15N usage and description
Carglumic acid 13C5 15N is a stable isotope-labeled form of Carglumic acid, a drug used for the treatment of hyperammonemia in patients with N-acetylglutamate synthase (NAGS) deficiency. This rare genetic disorder affects the urea cycle, leading to a build-up of ammonia in the body, which can cause severe neurological damage or even death. Carglumic acid acts as a co-factor for NAGS, which stimulates the production of urea and helps to remove excess ammonia from the body.
Carglumic acid 13C5 15N is used in clinical research to study the pharmacokinetics and metabolic pathways of Carglumic acid in the body. The stable isotope-labeled compound allows researchers to track the drug's movement and transformation within the body with greater precision and accuracy. This information can be used to optimize dosing regimens, evaluate drug interactions, and assess the safety and efficacy of Carglumic acid in patients.
In terms of chemical information, Carglumic acid 13C5 15N has a molecular formula of C6(13)C5H8(15)NO6 and a molecular weight of 224.14 g/mol. It is a white crystalline powder that is soluble in water and has a melting point of 158-161°C. The stable isotope labeling is achieved by incorporating five carbon-13 atoms and fifteen nitrogen-15 atoms into the molecular structure of the drug.
