Therapeutic Uses
Anti-Parkinsons
Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
Entacapone-d10, 1185241-19-3
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90 %
Hazard Compound
No -Refer MSDS for accurate information
Entacapone-d10 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
We are committed to offering products of the highest quality in order to meet the needs of our customers, and have elaborate systems in
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Entacapone-d10 usage and description
Entacapone D10 is a potent and selective inhibitor of catechol-O-methyltransferase (COMT), an enzyme that plays a crucial role in the metabolism of catecholamines such as dopamine, epinephrine, and norepinephrine. Entacapone D10 is used in the treatment of Parkinson's disease, a neurodegenerative disorder that affects the dopamine-producing neurons in the brain.
When Entacapone D10 is administered orally, it is rapidly absorbed and reaches peak plasma concentrations within 1-2 hours. The drug is extensively metabolized in the liver, primarily via glucuronidation and oxidation, and is excreted in the urine. The half-life of Entacapone D10 is approximately 2-3 hours, and it is typically administered three times per day in combination with levodopa and a dopamine agonist.
Entacapone D10 works by inhibiting the activity of COMT, which increases the concentration of levodopa in the brain and prolongs its effectiveness. Levodopa is a precursor to dopamine, and it is converted to dopamine in the brain. By increasing the concentration of levodopa in the brain, Entacapone D10 helps to alleviate the symptoms of Parkinson's disease, including tremors, rigidity, and bradykinesia.
Overall, Entacapone D10 is a valuable tool in the treatment of Parkinson's disease, and its chemical properties and mechanism of action make it an effective and well-tolerated medication.
