Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
Tetrabenazine-d6, 1392826-25-3
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
No -Refer MSDS for accurate information
Tetrabenazine-d6 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Tetrabenazine-d6 usage and description
Tetrabenazine D6 is a deuterated analogue of tetrabenazine, which is a medication primarily used to treat hyperkinetic movement disorders such as Huntington's disease, tardive dyskinesia, and Tourette syndrome. Tetrabenazine D6 is used in research and development studies as a stable isotope labeled compound.
The chemical formula of Tetrabenazine D6 is C19D6H21NO3, and it has a molecular weight of 335.45 g/mol. It is an inhibitor of vesicular monoamine transporter 2 (VMAT2), which regulates the uptake and storage of monoamines such as dopamine, serotonin, and norepinephrine within nerve terminals. By blocking VMAT2, tetrabenazine D6 reduces the availability of these neurotransmitters, thereby reducing the hyperkinetic movements associated with the aforementioned disorders.
As a stable isotope labeled compound, Tetrabenazine D6 is used in pharmacokinetic studies to measure the absorption, distribution, metabolism, and excretion of tetrabenazine in the body. It is also used in drug metabolism and drug-drug interaction studies to identify potential interactions with other medications.
In conclusion, Tetrabenazine D6 is a valuable tool for researchers studying the pharmacology and pharmacokinetics of tetrabenazine and related compounds. Its use has facilitated a better understanding of the mechanisms of action and potential drug interactions of tetrabenazine, which could lead to the development of safer and more effective treatments for hyperkinetic movement disorders.
