Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
Pyrimethamine-d3, 1189936-99-9
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
Yes -Refer MSDS for accurate information
Pyrimethamine-d3 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Pyrimethamine-d3 usage and description
Pyrimethamine D3 is a deuterated form of pyrimethamine, which is a medication used in the treatment of malaria and toxoplasmosis. Pyrimethamine D3 is a well-known antiprotozoal agent that selectively inhibits the dihydrofolate reductase (DHFR) enzyme of the parasite, which is essential for the synthesis of tetrahydrofolate (THF) that is required for the formation of nucleic acids. By inhibiting DHFR, Pyrimethamine D3 prevents the growth and replication of the parasite and ultimately leads to its death.
Pyrimethamine D3 is highly effective against Plasmodium falciparum, the most dangerous species of malaria, and Toxoplasma gondii, the causative agent of toxoplasmosis. It is often used in combination with other antimalarial agents, such as sulfadoxine, to achieve a synergistic effect and increase overall efficacy. Additionally, Pyrimethamine D3 is used in the prophylaxis of malaria in individuals traveling to endemic areas.
Chemically, Pyrimethamine D3 is a white to yellow crystalline powder that is sparingly soluble in water and ethanol. Its deuterated form offers several advantages over the non-deuterated version, including increased stability and improved pharmacokinetic properties, which can lead to enhanced therapeutic efficacy. Pyrimethamine D3 is generally well-tolerated, but some adverse effects may occur, such as gastrointestinal upset, headache, and dizziness. Overall, Pyrimethamine D3 is a valuable medication for the treatment and prevention of malaria and toxoplasmosis, and its deuterated form holds promise for further advancement in the field of antiprotozoal therapy.
