Storage Condition
Keep in a tightly closed vial, store in refrigerator
Synonyms
N-(2,6-dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)acetamide
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
No -Refer MSDS for accurate information
Ranolazine-d8 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
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Ranolazine-d8 usage and description
Ranolazine-d8 is a deuterated analog of ranolazine, a medication used for the treatment of chronic angina pectoris. It is a selective inhibitor of the late sodium current in cardiomyocytes, which reduces intracellular calcium overload and improves myocardial relaxation. Ranolazine-d8 can be used for pharmacokinetic studies and quantitative analysis in biological samples.
Chemically, ranolazine-d8 is a white to off-white crystalline powder with a molecular weight of 415.6 g/mol. It is soluble in water and ethanol, and has a melting point of 166-168°C. The deuterium substitution at the eight position of the ranolazine molecule can be detected by mass spectrometry and nuclear magnetic resonance spectroscopy, which allows for precise identification and quantification.
Ranolazine-d8 is typically administered orally, with a recommended starting dose of 500 mg twice daily. It is metabolized by the liver and excreted in the urine, with a half-life of approximately 7 hours. Due to its potential interactions with other medications and conditions, it is important to consult with a healthcare provider before taking ranolazine-d8.
Overall, ranolazine-d8 is a useful tool for researchers studying the pharmacokinetics and effects of ranolazine in the body. Its deuterium substitution allows for sensitive and accurate analysis, which can aid in the development of new treatments for angina and other cardiovascular conditions.
