Product Detail
Sofosbuvir Dimer
Sofosbuvir Impurity
Stock Status: In Stock
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For Research & Analytical Purposes. Not for Personal use.
Category
Impurity
API Family
Sofosbuvir
Storage
Store at refrigerator (2-8°C) for long term storage
Hazard Information
Refer MSDS for accurate information.
Sofosbuvir Dimer Product Information
Sofosbuvir Dimer is listed under Impurity. It is associated with Sofosbuvir and is intended for analytical research, quality control and pharmaceutical reference standard applications. The product is supplied by Clearsynth under CAT No. CS-O-11148.
Clearsynth provides this compound for research and analytical use, with product information including CAS number, molecular formula, molecular weight, stock enquiry details and supporting documentation.
Technical Data
Product Name
Sofosbuvir Dimer
CAS No.
1256490-29-5
CAT No.
CS-O-11148
Molecular Formula
C34H45FN4O13P2
Molecular Weight
798.69
Category
API Family
Storage Condition
Store at refrigerator (2-8°C) for long term storage
SMILES
CC(C)OC([C@H](C)NP(O[C@@H]1[C@H](O[C@@H](N2C(NC(C=C2)=O)=O)[C@@]1(F)C)COP(OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O)(OC4=CC=CC=C4)=O)=O
IUPAC Name
(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)amino)propanoate
Purity by HPLC
93.44%
Hazard Compound
Refer MSDS for accurate information.
Description
Overview
"Sofosbuvir 3’,5’-Bis-(S)-phosphate is an impurity of PSI-7977, a prodrug that is metabolized to the active antiviral agent 2’-deoxy-2’-a-fluoro-ß-C-methyluridine-5’-monophosphate and is currently being investigated in phase 3 clinical trials for the treat"
Synonyms
(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)amino)propanoate
Application Notes
"Sofosbuvir 3’,5’-Bis-(S)-phosphate is an impurity of PSI-7977, a prodrug that is metabolized to the active antiviral agent 2’-deoxy-2’-a-fluoro-ß-C-methyluridine-5’-monophosphate and is currently being investigated in phase 3 clinical trials for the treat"
References
"Lam, A,M,,et al,: Antimicrob, Agents, Chemotherapy,, 56, 3359 (2012); Lam, A,M,, et al,: J, Virol,, 85, 12334 (2011); Sofia, M,J,, et al,: J, Medn, Chem,, 53, 7202 (2010)"
