Therapeutic Uses
Immunosuppressants
Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
Leflunomida-d4; Leflunomidum-d4
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
Yes -Refer MSDS for accurate information
Leflunomide-d4 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Leflunomide-d4 usage and description
Leflunomide-d4 is a deuterated version of Leflunomide, a disease-modifying antirheumatic drug (DMARD) that is used to treat rheumatoid arthritis. This medication works by suppressing the immune system and reducing inflammation in the joints, which helps to alleviate the pain and swelling associated with this condition. Leflunomide-d4 is a labeled internal standard used in the analysis of Leflunomide by mass spectrometry.
Chemically, Leflunomide-d4 is a white to off-white crystalline powder, with a molecular formula of C12H4D4ClF3N2O2. It is classified as an isoxazole derivative, and its chemical structure is similar to that of teriflunomide, another DMARD used to treat multiple sclerosis. Leflunomide-d4 has a melting point of 106-107°C and a purity of at least 98%.
Leflunomide-d4 is typically administered orally as a tablet, with a recommended dosage of 20mg per day for adults. It is metabolized in the liver to form its active metabolite, teriflunomide, which has a much longer half-life than Leflunomide-d4 itself. Leflunomide-d4 is excreted primarily in the feces, with a small amount being eliminated in the urine.
In conclusion, Leflunomide-d4 is a helpful tool in the analysis of Leflunomide by mass spectrometry, and its use can aid in the development and monitoring of therapeutic treatments for rheumatoid arthritis.
