Therapeutic Uses
Antiretroviral / Anti-HIV
Synonyms
N-[(2′R)-2′-Deoxy-2′-fluoro-2′-(methyl-13C-d3)-5′-uridylyl]-L-alanine
Application Notes
Useful research chemical for a range of applications
Hazard Compound
Refer MSDS for complete information
Sofosbuvir Metabolite GS-566500-13C,d3 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Sofosbuvir Metabolite GS-566500-13C,d3 usage and description
Sofosbuvir metabolite GS-566500 13CD3 is a stable isotopic labeled version of GS-566500, a metabolite of the antiviral drug Sofosbuvir. Sofosbuvir is a direct-acting antiviral medication used in the treatment of chronic hepatitis C virus (HCV) infection. The drug works by inhibiting the HCV RNA polymerase, which is essential for viral replication. GS-566500 is one of the major metabolites of Sofosbuvir, formed by the cytochrome P450 system in the liver.
The stable isotopic labeled version of GS-566500, GS-566500 13CD3, is used in pharmacokinetic studies to assess the metabolism and elimination of Sofosbuvir in the body. This is done by administering a dose of Sofosbuvir to a patient and then monitoring the levels of GS-566500 and GS-566500 13CD3 in their blood or urine over time. The use of GS-566500 13CD3 allows for more accurate measurement of Sofosbuvir metabolism and elimination, which can help in determining optimal dosing regimens and predicting potential drug interactions.
Chemically, GS-566500 13CD3 is a labeled version of GS-566500, with three deuterium atoms replacing three hydrogen atoms in the molecule. Deuterium is a stable, non-radioactive isotope of hydrogen that has a slightly higher mass, making it useful for tracking the metabolism of drugs in the body. Overall, the use of GS-566500 13CD3 is an important tool in the development and optimization of Sofosbuvir therapy for patients with HCV infection.
