CAS No.
[1391051-97-0 (Relative Stereo)]
Storage Condition
Store at refrigerator (2-8°C) for long term storage
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 95 %
Hazard Compound
No -Refer MSDS for accurate information
Isosorbide-2-Mononitrate-13C6 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Isosorbide-2-Mononitrate-13C6 usage and description
Isosorbide-2-mononitrate 13C6, also known as ISMN-13C6, is a stable isotope-labeled analog of isosorbide-2-mononitrate (ISMN). ISMN is a medication used to prevent and treat angina pectoris, which is chest pain caused by insufficient blood flow to the heart. ISMN works by dilating the blood vessels, which reduces the workload of the heart and increases blood flow to the heart.
ISMN-13C6 is used in pharmacokinetic studies as a tracer to quantify drug metabolism and pharmacokinetics. It is also used in research to investigate the pharmacological effects of ISMN in humans and animals.
Chemically, ISMN-13C6 is a nitrate ester of isosorbide, which is a cyclic carbohydrate. It has the molecular formula C6H8N2O8^13C6 and a molecular weight of 260.14 g/mol. It is a white to off-white powder that is stable under normal conditions.
The metabolism of ISMN-13C6 is similar to that of ISMN. It is rapidly absorbed in the gastrointestinal tract and undergoes first-pass metabolism in the liver, where it is converted to the active metabolite, isosorbide-5-mononitrate. The half-life of ISMN-13C6 is approximately 5 hours, and it is primarily excreted in the urine.
In conclusion, ISMN-13C6 is a useful tool in pharmacokinetic and pharmacological research of ISMN. Its chemical properties and metabolism are similar to ISMN, and it is a safe and stable isotope-labeled analog.
