Therapeutic Uses
Anti-Cancer / Oncology
Storage Condition
Refer MSDS for complete information
Synonyms
Gefitinib Impurity VIII; 4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
Application Notes
Useful research chemical for a range of applications
Hazard Compound
Refer MSDS for complete information
4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate usage and description
4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate is a chemical compound that belongs to the class of quinazoline derivatives. It is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, which plays a crucial role in the regulation of cell proliferation, differentiation, and survival. EGFR is overexpressed in many types of cancer, including lung cancer, breast cancer, and head and neck cancer. Therefore, 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate has been developed as a promising anticancer agent.
The chemical formula of 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate is C18H14ClFN4O3, and its molecular weight is 398.78 g/mol. It is a yellowish crystalline powder that is soluble in dimethyl sulfoxide (DMSO) and methanol. The melting point of 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate is between 239-241°C.
The recommended usage of 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate is as an EGFR tyrosine kinase inhibitor for the treatment of various types of cancer. It can be administered orally, and its dosage depends on the patient's condition and the severity of the disease. However, it is important to note that this compound may cause adverse effects, such as diarrhea, fatigue, skin rash, and nausea, among others. Therefore, it should only be used under the supervision of a qualified healthcare professional.
