CAS No.
[1231930-33-8 (Unlabeled)]
Therapeutic Uses
Anti-Cancer / Oncology
Storage Condition
Refer MSDS for complete information
Synonyms
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1h-benzo[d]imidazole-D12
Application Notes
Useful research chemical for a range of applications
Hazard Compound
Refer MSDS for complete information
Abemaciclib Impurity 1-d12 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Abemaciclib Impurity 1-d12 usage and description
Abemaciclib Impurity 1 D12 is a chemical compound that is used in the research and development of cancer treatments, specifically those targeting cyclin-dependent kinases (CDKs). CDKs are a family of proteins that regulate the cell cycle, and their dysregulation is a hallmark of cancer. Abemaciclib Impurity 1 D12 is a stable isotope-labeled compound that can be used in experiments to track the metabolism and pharmacokinetics of abemaciclib, a CDK4/6 inhibitor that is currently used in the treatment of certain types of breast cancer.
The chemical formula of Abemaciclib Impurity 1 D12 is C27H32D12N8O2, and its molecular weight is 498.66 g/mol. It is a white to off-white powder that is soluble in dimethyl sulfoxide (DMSO), methanol, and ethanol. Abemaciclib Impurity 1 D12 is stable under normal laboratory conditions and can be stored at room temperature.
When used in experiments, Abemaciclib Impurity 1 D12 is typically administered to cells or animals along with abemaciclib to track the metabolism and distribution of the drug. It can also be used to quantify the amount of abemaciclib in biological samples using mass spectrometry. By understanding how abemaciclib is metabolized and distributed in the body, researchers can optimize its dosing and efficacy, leading to better treatments for cancer patients.
