CAS No.
[1217853-93-4 (Unlabelled)]
Storage Condition
Refer MSDS for complete information
Synonyms
(S)-4-(2-((3-((9H-carbazol-4-yl)oxy)-2-hydroxypropyl)amino)ethoxy)-3-(methoxy-d3)phenol
Application Notes
Useful research chemical for a range of applications
Hazard Compound
Refer MSDS for complete information
(S)-4-Hydroxycarvedilol-D3 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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(S)-4-Hydroxycarvedilol-D3 usage and description
(S)-4-Hydroxycarvedilol-D3 is a deuterium-labeled version of the active metabolite of Carvedilol, a medication used to treat high blood pressure and heart failure. This compound is used in research and clinical settings to study the metabolism and pharmacokinetics of Carvedilol.
The chemical name of (S)-4-Hydroxycarvedilol-D3 is (2S)-1-{[2-(6-methoxy-2,3-dihydro-1H-inden-4-yl)-1-(propan-2-yl)amino]propan-2-yl}oxy-4-(2-hydroxy-3-(propan-2-ylamino)propoxy)indan-1-one-d3. The deuterium-labeled version contains three extra neutrons, which can be used to track the compound in biological systems.
(S)-4-Hydroxycarvedilol-D3 is metabolized in the liver by the cytochrome P450 enzyme system, specifically by the CYP2D6 enzyme. It is converted to glucuronide and sulfate conjugates, which are excreted in the urine. The half-life of (S)-4-Hydroxycarvedilol-D3 is approximately 7-10 hours.
In conclusion, (S)-4-Hydroxycarvedilol-D3 is a useful tool for studying the metabolism and pharmacokinetics of Carvedilol. Its deuterium labeling allows for easy tracking in biological systems, and its metabolism and excretion pathways have been well-characterized.
