Therapeutic Uses
Immunosuppressants
API Family
Mycophenolic Acid
Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
(Z)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90 %
Hazard Compound
No -Refer MSDS for accurate information
(Z)-Mycophenolic Acid is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
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(Z)-Mycophenolic Acid usage and description
(Z)-Mycophenolic Acid is a naturally occurring compound that has been used in medicine for its immunosuppressive properties. It is an isomer of mycophenolic acid, a fungal metabolite that was first discovered in 1896. (Z)-Mycophenolic Acid is typically used in the form of its prodrug, mycophenolate mofetil, which is an ester that is rapidly converted to the active form in the body.
The primary use for (Z)-Mycophenolic Acid is in the prevention of transplant rejection. It works by inhibiting the proliferation of T and B lymphocytes, which are involved in the immune response. This makes it useful in preventing rejection of transplanted organs, as well as in the treatment of autoimmune disorders such as lupus and rheumatoid arthritis.
Chemically, (Z)-Mycophenolic Acid is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH), which is an enzyme involved in the synthesis of guanine nucleotides. By inhibiting this enzyme, (Z)-Mycophenolic Acid reduces the production of nucleotides that are necessary for DNA synthesis and cell proliferation. This is what makes it effective in suppressing the immune response, as immune cells require rapid proliferation in order to mount an effective response.
Overall, (Z)-Mycophenolic Acid is an important tool in the prevention of transplant rejection and the treatment of autoimmune disorders. Its chemical properties make it a potent inhibitor of IMPDH, which is what gives it its immunosuppressive properties.
