References
"Stahl, et al,: Chem, Res, Toxicol,, 5, 106 (1992), Kokkinakis, D,M,, et al,: Clin, Cancer Res,, 5(11), 3676 (1999), Hickman, M,J,, et al,: Proc, Natl, Acad, Sci, USA, 96(19), 10764 (1999),"
Synonyms
Carmustine EP Impurity A; N,N′-Bis(2-chloroethyl)urea (ACI); Urea, 1,3-bis(2-chloroethyl)- (6CI, 7CI, 8CI); 1,3-Bis(2-chloroethyl)urea; NSC 36198
Application Notes
"1,3-Bis(2-chloroethyl)urea is an impurity in the synthesis of Carmustine , an alkylating and carbamoylating nitrosourea compound. It interacts with DNA, RNA and proteins causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death.;Impurity in commercial preparations of Carmustine"
