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For Research Purposes only. Not for Personal use.
All compounds supplied are strictly intended for laboratory, research, analytical, and scientific use only. They are not meant for human consumption, therapeutic use, or any form of clinical application.
CAS No.
-
Product Code
CS-T-100977
M.F.
C26H18D8F3N7O2
M.W.
533.57
Category
Stable Isotopes
Storage Condition
Refer MSDS for complete information.
IUPAC Name
BAY 87-2243-d8
References
"Ellinghaus, P., et al.: Cancer Med., 2, 611 (2013)"
Isotope labelled BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation. It is found to inhibit HIF-1a and HIF-2a protein accumulation under hypoxic conditions in non-small cell lung cancer cell line H460. It inhibits mitochondrial complex I activity and therefore may be used in antitumor treatment to overcome chemo- and radiotherapy- resistance of hypoxic tumors.
Hazard Compound
Refer MSDS for complete information.
Overview
Isotope labelled BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation. It is found to inhibit HIF-1a and HIF-2a protein accumulation under hypoxic conditions in non-small cell lung cancer cell line H460. It inhibits mitochondrial complex I activity and therefore may be used in antitumor treatment to overcome chemo- and radiotherapy- resistance of hypoxic tumors.
