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CAS No.
-
Product Code
CS-T-101077
M.F.
C25H22D6Cl2N2O8
M.W.
561.44
Category
Stable Isotopes
Storage Condition
Refer MSDS for complete information.
IUPAC Name
Di-O-glycinoylcurcumin-d6 Dihydrochloride
References
"Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007), Chem. and Eng. News 90(31), 44 (2012)"
"Di-O-glycinoylcurcumin-d6 Dihydrochloride is the isotope labelled analog of Di-O-glycinoylcurcumin Dihydrochloride. Di-O-glycinoylcurcumin Dihydrochloride is a metabolite of curcumin (C838500), which is a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and I?B kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nu"
Hazard Compound
Refer MSDS for complete information.
Overview
"Di-O-glycinoylcurcumin-d6 Dihydrochloride is the isotope labelled analog of Di-O-glycinoylcurcumin Dihydrochloride. Di-O-glycinoylcurcumin Dihydrochloride is a metabolite of curcumin (C838500), which is a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and antioxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and I?B kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nu"
