O-tert-Butyl-dimethylsilyl Curcumin-d6

2734308-81-5

CS-T-101758

C₂₇H₂₈D₆O₆Si

488.68

CC(C)(C)[Si](C)(C)OC1=C(C=C(C=C1)/C=C/C(O)=C/C(/C=C/C2=CC(OC([2H])([2H])[2H])=C(C=C2)O)=O)OC([2H])([2H])[2H]

Stable Isotopes

Refer MSDS for complete information.

(1E,4Z,6E)-7-[4-[tert-butyl(dimethyl)silyl]oxy-3-(trideuteriomethoxy)phenyl]-5-hydroxy-1-[4-hydroxy-3-(trideuteriomethoxy)phenyl]hepta-1,4,6-trien-3-one

"Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953); Tu, B., et al.: J .Cell Biol., 164, 341 (2004); Xu, G., et al.: Biochemistry, 44, 9817 (2005); Johnson, J., et al.: Cancer Lett., 255, 170 (2007)"

"(1E,4Z,6E)-7-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one-d6"

"O-tert-Butyl-dimethylsilyl Curcumin-d6 is the labeled form of O-tert-Butyl-dimethylsilyl Curcumin (B691020), which is a protected Curcumin (C838500). A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and I?B kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope."

Refer MSDS for complete information.