5-Fluoroorotic Acid Monohydrate-13C15N2

-

CS-T-102235

C₄¹³CH₅F¹₅N₂O₅

195.08

Stable Isotopes

Refer MSDS for complete information.

5-Fluoroorotic Acid Monohydrate-13C15N2

"Winston, F., et al.: Genetics, 107, 179 (1984); Boeke, J.D., et al.: Methods Enzymol., 154, 164 (1987); Rathod, P.K., et al.: Antimicrob. Agents Chemother., 33, 1090 (1989); Rathod, P.K., et al.: Antimicrob. Agents Chemother., 36, 704 (1992); Gomez, Z.M ."

5-FOA-13C15N2

"5-Fluoroorotic Acid Monohydrate-13C15N2 is the isotope analog of 5-Fluoroorotic Acid Monohydrate, (5-FOA). 5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroqu"

Refer MSDS for complete information.