CAS No.
146464-95-1(unlabelled)
Smiles
C#CCC(C1=CC=C(C(N[15C@H]([15C](O)=O)[15CH2][15CH2][15C](O)=O)=O)C=C1)CC2=CN=C3C(C(N)=NC(N)=N3)=N2
Storage Condition
Refer MSDS for complete information
IUPAC Name
N-[4-[1-[(2,4-Diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-L-glutamic Acid-15C5; N-[4-[1-[(2,4-Diamino-6-pteridinyl)methyl]-3-butynyl]benzoyl]-L-glutamic Acid-15C5; 10-Propargyl-10-deazaaminopterin-15C5; Folotyn-15C5; PDX-15C5
References
Krug, L.M. et al.: Clin. Cancer Res., 6, 3493 (2000); O'Connor, O.A. et al.: Br. J. Haematol., 139, 425 (2007); O'Connor, O.A. et al.: J. Clin. Oncol., 29, 1182 (2011)
Synonyms
N-[4-[1-[(2,4-Diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-L-glutamic Acid-15C5; N-[4-[1-[(2,4-Diamino-6-pteridinyl)methyl]-3-butynyl]benzoyl]-L-glutamic Acid-15C5; 10-Propargyl-10-deazaaminopterin-15C5; Folotyn-15C5; PDX-15C5
Application Notes
Pralatrexate-15C5 is labelled Pralatrexate (P700500) which is an antifolate with high affinity for the reduced folate carrier-type 1 that produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma.
Hazard Compound
Refer MSDS for complete information
Pralatrexate-15C5 is labelled Pralatrexate (P700500) which is an antifolate with high affinity for the reduced folate carrier-type 1 that produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma.
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