Product Detail
Aprepitant-d4 N-Oxide
Aprepitant Metabolite
Stock Status: Enquire
Live
For Research & Analytical Purposes. Not for Personal use.
Category
Metabolite
API Family
Aprepitant
Storage
Refer MSDS for complete information.
Hazard Information
Refer MSDS for complete information.
Aprepitant-d4 N-Oxide Product Information
Aprepitant-d4 N-Oxide is listed under Metabolite. It is associated with Aprepitant and is intended for analytical research, quality control and pharmaceutical reference standard applications. The product is supplied by Clearsynth under CAT No. CS-T-103829.
Clearsynth provides this compound for research and analytical use, with product information including CAS number, molecular formula, molecular weight and product enquiry details.
Technical Data
Product Name
Aprepitant-d4 N-Oxide
CAS No.
172673-23-3(unlabelled)
CAT No.
CS-T-103829
Molecular Formula
C₂₃H₁₇D₄F₇N₄O₄
Molecular Weight
554.45
Category
API Family
Storage Condition
Refer MSDS for complete information.
SMILES
C[C@@H](O[C@@H]1[C@H](C2=C([2H])C([2H])=C(F)C([2H])=C2[2H])[N+](CC3=NNC(N3)=O)([O-])CCO1)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
IUPAC Name
[2R-[2α(R*),3α]]-5-[[2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl-d4)-4-oxido-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
Hazard Compound
Refer MSDS for complete information.
Description
Overview
Aprepitant-d4 N-Oxide is labelled Aprepitant N-Oxide (A729825) which is an impurity of Fosaprepitant (F727300), a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.
Synonyms
[2R-[2α(R*),3α]]-5-[[2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl-d4)-4-oxido-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
Application Notes
Aprepitant-d4 N-Oxide is labelled Aprepitant N-Oxide (A729825) which is an impurity of Fosaprepitant (F727300), a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug, a Aprepitant (A729800) prodrug.
References
Tattersall, F., et al.: Neuropharmacol., 39, 652 (2000), Cocquyt, V., et al.: Eur. J. Canc., 37, 835 (2001), Lasseter, K., et al.: J. Clin. Pharmacol., 47, 834 (2007), Marbury, T., et al.: Anesthes., Analges., 109, 418 (2009)
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