Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
Brimonidine Impurity I
Application Notes
Useful research chemical for a range of applications
Hazard Compound
Yes -Refer MSDS for accurate information
5-Bromo-6-isothiocyanatoquinoxaline is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
Refund Policy
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5-Bromo-6-isothiocyanatoquinoxaline usage and description
5-Bromo-6-isothiocyanatoquinoxaline (BIQ) is a chemical compound that is widely used in various research applications, particularly in the field of neuroscience. It is commonly used as a selective antagonist of the AMPA-type glutamate receptors, which are important for synaptic plasticity and memory formation in the brain.
BIQ is known to bind specifically to the GluA2 subunit of the AMPA receptor, blocking the receptor's ion channel and preventing the influx of calcium ions that are necessary for neuronal signaling. This makes it a valuable tool for studying the role of AMPA receptors in various brain functions, such as learning and memory, and for investigating potential therapeutic targets for neurological disorders.
In addition to its use in neuroscience research, BIQ has also been studied for its potential as an anti-cancer agent. It is believed to induce apoptosis, or programmed cell death, in cancer cells by activating the p38 mitogen-activated protein kinase pathway.
The chemical structure of BIQ consists of a quinoxaline ring system with a bromine atom and an isothiocyanate group attached at positions 5 and 6, respectively. It has a molecular weight of 289.14 g/mol and a melting point of 174-176°C.
Overall, BIQ is a valuable research tool with potential applications in both neuroscience and cancer research. Its specific binding to AMPA receptors and ability to induce apoptosis make it a promising compound for further study and potential therapeutic development.
