Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
Busulfan-d8, 116653-28-2
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
Yes -Refer MSDS for accurate information
Busulfan-d8 is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Busulfan-d8 usage and description
Busulfan D8, also known as deutero-busulfan, is a deuterium-labeled form of the chemotherapy drug Busulfan. Busulfan D8 is commonly used as a stable isotope-labeled internal standard in mass spectrometry-based assays to accurately quantify the levels of Busulfan in biological samples.
Busulfan D8 works by preventing DNA replication and cellular division, effectively killing cancer cells. It is primarily used in the treatment of chronic myeloid leukemia, a type of blood cancer that affects the bone marrow. Busulfan D8 is administered orally or intravenously and is typically given in multiple cycles over several months.
The chemical structure of Busulfan D8 is similar to that of Busulfan, with the addition of eight deuterium atoms. This isotopic labeling improves the accuracy and precision of analytical methods used to measure Busulfan levels in biological samples, as it reduces the effects of chemical and biological variability on the measurements.
Despite its effectiveness in treating cancer, Busulfan D8 is not without side effects. Common side effects include nausea, vomiting, diarrhea, fatigue, and hair loss. More serious side effects can include liver and kidney damage, lung problems, and an increased risk of developing secondary cancers.
In conclusion, Busulfan D8 is an important tool for cancer research and treatment, providing accurate measurement of Busulfan levels in biological samples. Its use in combination with other chemotherapy drugs can help improve patient outcomes and increase survival rates.
