Therapeutic Uses
Anti-Cancer / Oncology
Storage Condition
Store at refrigerator (2-8°C) for long term storage
Synonyms
Capecitabine-2',3'-cyclic Carbonate, 921769-65-5
Application Notes
Useful research chemical for a range of applications
Purity by HPLC
Not less than 90%
Hazard Compound
No -Refer MSDS for accurate information
Capecitabine-2',3'-cyclic Carbonate is a drug product that is used as an analytical standard for HPLC, as well as in research and development of drugs.
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Capecitabine-2',3'-cyclic Carbonate usage and description
Capecitabine-2',3'-cyclic Carbonate is a prodrug of Capecitabine, which is an orally administered chemotherapy agent used in the treatment of various types of cancer, including breast, colorectal, and gastric cancers. Capecitabine-2',3'-cyclic Carbonate is designed to improve the bioavailability and efficacy of Capecitabine by increasing its stability and solubility in the gastrointestinal tract.
Upon oral administration, Capecitabine-2',3'-cyclic Carbonate is converted to Capecitabine in the body by the action of esterases. Capecitabine is then further metabolized to 5-fluorouracil (5-FU), which is a cytotoxic agent that disrupts DNA synthesis and inhibits cell growth. The conversion of Capecitabine to 5-FU occurs mainly in tumor cells, which allows for targeted cancer treatment with minimal systemic toxicity.
The chemical structure of Capecitabine-2',3'-cyclic Carbonate includes a cyclic carbonate group, which contributes to its improved stability and solubility properties. The compound has a molecular weight of 476.53 g/mol and a melting point of 200-205°C. Capecitabine-2',3'-cyclic Carbonate is sparingly soluble in water but readily soluble in organic solvents such as ethanol and methanol.
In summary, Capecitabine-2',3'-cyclic Carbonate is a prodrug of Capecitabine that is designed to improve the bioavailability and efficacy of this chemotherapy agent. The compound is converted to Capecitabine in the body and further metabolized to 5-FU, which is a cytotoxic agent that inhibits cell growth. The cyclic carbonate group in the chemical structure of Capecitabine-2',3'-cyclic Carbonate contributes to its improved stability and solubility properties.
