Smiles
O[C@@]12N(C([C@](C)(O2)NC([C@@H]3C[C@]4([H])C5=CC=CC6=C5C(C[C@@]4([H])N(C3)C)=CN6)=O)=O)[C@H](C(N7[C@@]1([H])CCC7)=O)CC8=CC=CC=C8
API Family
Dihydroergotamine
Storage Condition
Store at freezer (-20°C) for long term storage
IUPAC Name
(6aR,9R,10aR)-N-((2S,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide
References
"French, W,N,, et al,: J, Pharma, Sci,, 54, 1515 (1965); "
Synonyms
(2′β,5′α)-9,10-Dihydro-12′-hydroxy-2′-methyl-5′-(phenylmethyl)ergotaman-3′,6′,18-trione (ACI); Aciergotamine, dihydro- (6CI, 7CI); 2′-Epidihydroergotamine
Application Notes
2'-Epidihydroergotamine is an ergot alkaloid that exhibits potential neuroprotective properties against degenerative diseases.
Purity by HPLC
Not less than 90%
Hazard Compound
Refer MSDS for accurate information
2'-Epidihydroergotamine is an ergot alkaloid that exhibits potential neuroprotective properties against degenerative diseases.
Refund Policy
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Dihydroergotamine Mesylate Impurity D usage and description
Dihydroergotamine Mesylate Impurity D, also known as 8'-hydroxy-dihydroergotamine, is a chemical impurity that can be found in the synthesis of Dihydroergotamine Mesylate, a medication used to treat migraines. This impurity is a metabolite of Dihydroergotamine and is formed through the oxidation of the 8'-position of the indole ring.
While Dihydroergotamine Mesylate is the active ingredient in the medication, impurities such as Impurity D can affect the potency and stability of the drug. Therefore, it is important to monitor and control the levels of impurities during the manufacturing process.
Chemically, Impurity D has a molecular weight of 555.66 g/mol and a molecular formula of C33H37N5O3. It has a melting point of 232-234°C and is soluble in ethanol and methanol.
In terms of usage, Impurity D may not have any therapeutic benefits and may even have potential side effects. Therefore, it is important to control and minimize the levels of impurities in the final product to ensure the safety and efficacy of the medication.
Overall, understanding the chemical properties and usage of Dihydroergotamine Mesylate Impurity D is crucial for the development and manufacturing of safe and effective medication for migraine sufferers.
